Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
Identifieur interne : 001B78 ( Main/Exploration ); précédent : 001B77; suivant : 001B79Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
Auteurs : Susanne A. Schneider [Royaume-Uni, Allemagne] ; Burkhard Pleger [Royaume-Uni, Allemagne] ; Bogdan Draganski [Royaume-Uni, Allemagne] ; Carla Cordivari [Royaume-Uni] ; John C. Rothwell [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Ray J. Dolan [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Basal ganglion, Brain Mapping, Discrimination, Discrimination (Psychology) (physiology), Dystonia, Dystonic Disorders (pathology), Dystonic Disorders (physiopathology), Evoked Potentials, Somatosensory (physiology), Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Nuclear magnetic resonance imaging, Oxygen (blood), Premotor cortex, Sensorimotor cortex, Somatosensory Cortex (blood supply), Somatosensory Cortex (physiopathology), Somatosensory cortex, Statistics, Nonparametric, TMS, Transcranial Magnetic Stimulation (methods), Writer cramp, basal ganglia, fMRI, premotor cortex, primary dystonia, repetitive TMS, sensorimotor cortex, sensory discrimination, writer's cramp.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Somatosensory Cortex.
- methods : Image Processing, Computer-Assisted, Transcranial Magnetic Stimulation.
- pathology : Dystonic Disorders.
- physiology : Discrimination (Psychology), Evoked Potentials, Somatosensory.
- physiopathology : Dystonic Disorders, Somatosensory Cortex.
- Adult, Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Statistics, Nonparametric.
Abstract
Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/A00257E644BA6906FB30146744D4A341941D570A/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929458
DOI: 10.1002/mds.22825
Affiliations:
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Schneider</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Schilling Section of Clinical and Molecular Neurogenetics, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea><wicri:noRegion>UCL</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Draganski, Bogdan" sort="Draganski, Bogdan" uniqKey="Draganski B" first="Bogdan" last="Draganski">Bogdan Draganski</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea><wicri:noRegion>UCL</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dolan, Ray J" sort="Dolan, Ray J" uniqKey="Dolan R" first="Ray J." last="Dolan">Ray J. Dolan</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea><wicri:noRegion>UCL</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-15">2010-01-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="76">76</biblScope><biblScope unit="page" to="83">83</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A00257E644BA6906FB30146744D4A341941D570A</idno><idno type="DOI">10.1002/mds.22825</idno><idno type="ArticleID">MDS22825</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Basal ganglion</term><term>Brain Mapping</term><term>Discrimination</term><term>Discrimination (Psychology) (physiology)</term><term>Dystonia</term><term>Dystonic Disorders (pathology)</term><term>Dystonic Disorders (physiopathology)</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Nuclear magnetic resonance imaging</term><term>Oxygen (blood)</term><term>Premotor cortex</term><term>Sensorimotor cortex</term><term>Somatosensory Cortex (blood supply)</term><term>Somatosensory Cortex (physiopathology)</term><term>Somatosensory cortex</term><term>Statistics, Nonparametric</term><term>TMS</term><term>Transcranial Magnetic Stimulation (methods)</term><term>Writer cramp</term><term>basal ganglia</term><term>fMRI</term><term>premotor cortex</term><term>primary dystonia</term><term>repetitive TMS</term><term>sensorimotor cortex</term><term>sensory discrimination</term><term>writer's cramp</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term><term>Evoked Potentials, Somatosensory</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonic Disorders</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex prémoteur</term><term>Cortex sensorimoteur</term><term>Cortex somatosensoriel</term><term>Crampe écrivain</term><term>Discrimination</term><term>Dystonie</term><term>Imagerie RMN</term><term>Noyau gris central</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Leipzig</li><li>Grand Londres</li><li>Saxe (Land)</li></region><settlement><li>Leipzig</li><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name></region><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><name sortKey="Dolan, Ray J" sort="Dolan, Ray J" uniqKey="Dolan R" first="Ray J." last="Dolan">Ray J. Dolan</name><name sortKey="Dolan, Ray J" sort="Dolan, Ray J" uniqKey="Dolan R" first="Ray J." last="Dolan">Ray J. Dolan</name><name sortKey="Draganski, Bogdan" sort="Draganski, Bogdan" uniqKey="Draganski B" first="Bogdan" last="Draganski">Bogdan Draganski</name><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name></country><country name="Allemagne"><noRegion><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name></noRegion><name sortKey="Draganski, Bogdan" sort="Draganski, Bogdan" uniqKey="Draganski B" first="Bogdan" last="Draganski">Bogdan Draganski</name><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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